Averaz Powder for Suspension for Injection

Azacitidine

100 mg

MSN LABORATORIES PRIVATE LIMITED

Pack size	1 Vial (4 ml)
Dispensing mode
Source
Agent
Retail Price	1041.65 AED

Indications

Averaz Powder for Suspension for Injection is used for: For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Azacitidine :

Mechanism of Action

Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine may induce antineoplastic activity by inhibition of DNA methyltransferase at low doses and cytotoxicity through incorporation into RNA and DNA at high doses. Covalent binding to DNA methyltransferase results in hypomethylation of DNA and prevents DNA synthesis. As azacitidine is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein, resulting in cell death.

Note

Averaz 100 mg Powder for Suspension for Injection manufactured by MSN LABORATORIES PRIVATE LIMITED. Its generic name is Azacitidine. Averaz is availble in Saudi Arabia. Farmaco SA drug index information on Averaz Powder for Suspension for Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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