GASTROZOLE PLUS Capsule
Omeprazole 20mg + Sodium bicarbonate 1100mg
40 mg + 1100 mg
Riyadh Pharma (Medical and Cosmetic Products Company Ltd.)
| Pack size | 28's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 4.07 AED |
Available as:
Indications
GASTROZOLE PLUS Capsule is used for:
Peptic ulcer disease, Gastroesophageal Reflux Disease (GERD), Erosive Esophagitis
Adult Dose
Oral
Usually once daily on an empty stomach, at least 1 hour before a meal.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Contra Indications
Patients with known hypersensitivity to any components of the formulation.
Precautions
Exclude malignancy, prolonged use, hepatic impairment. Pregnancy, lactation, children <1 yr.
Lactation: Distributes into human breast milk; avoid use
Pregnancy-Lactation
Interactions
Omeprazole: Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time w/ warfarin. Increased risk of digoxin-induced cardiotoxic effects. May increase plasma concentration benzodiazepines (e.g. diazepam), clarithromycin and methotrexate. Decreased absorption of itraconazole, ketoconazole, posaconazole, dasatinib, iron salts. May prolong elimination of diazepam, cilostazol, phenytoin and ciclosporin. May reduce the antiplatelet effect of clopidogrel.
Potentially Fatal: May decrease plasma concentrations and pharmacological effects of rilpivirine, nelfinavir and atazanavir.
Sodium bicarbonate: Increases toxicity of amphetamines, ephedrine, pseudoephedrine, flecainide, quinidine and quinine. Decreases effects of lithium, chlorpropamide and salicylates due to increased clearance. May affect the absorption of certain drugs due to raised intra-gastric pH.
Adverse Effects
Side effects of Omeprazole 20mg + Sodium bicarbonate 1100mg :
>10%
Pyrexia (20%), Hypokalemia (12%), Hyperglycemia (11%), Nosocomial pneumonia (11%)
1-10%
Hypotension (10%), Hypomagnesemia (10%), Hypertension (8%), Atrial fibrillation (6%), Hypocalcemia (6%), Rash (6%), Tachycardia (5%), Constipation (5%), Sepsis (5%), Hyperpyrexia (5%), Oral candidiasis (4%), Bradycardia (4%), Diarrhea (4%), Edema (3%), Supraventricular tachycardia (3%), Decubitus ulcer (3%), Agitation (3%), Hypernatremia (2%), Hyperkalemia (2%), Urinary tract infection (2%), Hypomotility (2%), Candidal infection (2%)
<1%
Angina, Fracture, Glycosuria, Anemia, Hepatic failure, Benign gastric polyps, Agranulocytosis, Alopecia, Increased creatinine, Hemolytic anemia, Angioedema, Gynecomastia, Anorexia, Hepatic encephalopathy, Metabolic alkalosis, Pancreatitis, Photosensitivity, Liver disease
Potentially Fatal: Anaphylaxis.
Mechanism of Action
Omeprazole is a substituted benzimidazole gastric antisecretory agent and is also known as PPI. It blocks the final step in gastric acid secretion by specific inhibition of H+/K+ ATPase enzyme system present on the secretory surface of the gastric parietal cell. Both basal and stimulated acid are inhibited.
Sodium bicarbonate raises blood and urinary pH by dissociation to provide bicarbonate ions, which neutralises the hydrogen ion concentration. It also neutralises gastric acid via production of carbon dioxide.
Note
GASTROZOLE PLUS 40 mg + 1100 mg Capsule manufactured by Riyadh Pharma (Medical and Cosmetic Products Company Ltd.). Its generic name is Omeprazole 20mg + Sodium bicarbonate 1100mg. GASTROZOLE PLUS is availble in Saudi Arabia.
Farmaco SA drug index information on GASTROZOLE PLUS Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.