PROTELOS Granules for Oral Suspension
Strontium Renalate
2 gm
SERVIER (IRELAND) INDUSTRIES LTD.
| Pack size | 28's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 8.20 AED |
Indications
PROTELOS Granules for Oral Suspension is used for:
Postmenopausal osteoporosis
Adult Dose
Oral
Postmenopausal osteoporosis
Adult: 2 g daily.
Elderly: No dosage adjustment needed.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Renal Dose
Renal impairment: No dosage adjustment needed.
CrCl (ml/min) Dosage Recommendation
<30 Not recommended.
Administration
Should be taken on an empty stomach. Take on an empty stomach between meals, preferably at bedtime at least 2 hr after food, milk, milk products or Ca supplements. Mix only w/ plain water & drink immediately.
Contra Indications
Patients w/ current or previous venous thromboembolic events including deep vein thrombosis and pulmonary embolism; temporary or permanent immobilisation due to post-surgical recovery or prolonged bed rest; current or history of ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease; uncontrolled HTN. Lactation.
Precautions
Not recommended for use in patients with CrCl <30 ml/min. Patients at increased risk of venous thromboembolism. Pregnancy.
Pregnancy-Lactation
Pregnancy Category: D
Lactation: excreted in breast milk
Interactions
May reduce the absorption of oral tetracycline and quinolone antibiotics. Medicinal products containing Ca may reduce strontium ranelate bioavailability.
Adverse Effects
Side effects of Strontium Renalate :
Headache, GI disturbances, eczema, dermatitis; memory loss, consciousness disturbances, seizures, pyrexia, peripheral oedema, confusion, bronchial hyperreactivity. Angioedema, rash, urticaria, pruritus. Transient increases in creatine kinase activity (reversible).
Potentially Fatal: Toxic epidermal necrolysis, Stevens-Johnson syndrome, and drug rash w/ eosinophilia and systemic symptoms.
Mechanism of Action
Strontium ranelate stimulates bone formation, osteoblast precursor replication and collagen synthesis. Decreasing osteoclast differentiation and resorbing activity, it reduces bone resorption resulting in a rebalance of bone turnover in favour of bone formation.
Note
PROTELOS 2 gm Granules for Oral Suspension manufactured by SERVIER (IRELAND) INDUSTRIES LTD.. Its generic name is Strontium Renalate. PROTELOS is availble in Saudi Arabia.
Farmaco SA drug index information on PROTELOS Granules for Oral Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.