RIBOLISIN Eye Drops, Solution

Sodium Hyaluronate

0.15%

Sooft Italia SBA

Pack size	15 Single Dose Container
Dispensing mode
Source
Agent
Retail Price	0.93 AED

Indications

RIBOLISIN Eye Drops, Solution is used for: Osteoarthritis

Adult Dose

Intra-articular Adult: Osteoarthritis of Knee Indicated for treatment of pain in osteoarthritis of the knee Inject 20 mg (2 mL) once wkly for 3-5 weeks.

Child Dose

Safety & efficacy not established

Renal Dose

Administration

Contra Indications

Hypersensitivity to sodium hyaluronate or avian proteins. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site.

Precautions

Use caution when injecting Sodium Hyaluronate into patients who are allergic to avian proteins, feathers, and egg products. Strict aseptic administration technique must be followed. Remove joint effusion, if present, before injecting Sodium Hyaluronate. Do not use the same syringe for removing joint effusion and for injecting Sodium Hyaluronate. It is recommended that the patient avoid any strenuous activities or prolonged (i.e., more than 1 hour) weight-bearing activities such as jogging or tennis within 48 hours following the intra-articular injection. Lactation: Unknown whether distributed in breast milk, caution advised

Pregnancy-Lactation

Pregnancy Category: N/A Lactation: Not known if excreted in breast milk; not recommended

Interactions

The safety and effectiveness of the use of sodium hyaluronate concomitantly with other intra-articular injection has not yet been established. As sodium hyaluronate is precipitated by quaternary amine bactericides or disinfectants eg, benzalkonium chloride and chlorhexidine, etc, adequate attention should be given.

Adverse Effects

Side effects of Sodium Hyaluronate : >10% Arthralgia (25%), Tenderness (61-92%), Swelling (81-91%), Firmness (88-89%), Bruising (52-87%), Pruritus (25-36%), Skin discoloration (33-78%), Firmness (86-89%), Lumps/bumps (56-83%) 1-10% Increased blood pressure (4%), Fatigue (1%), Nausea (<2%), Injection site pain (3%), Paresthesia (1%), Tendonitis (2%), Limb pain (1%), Tendonitis (2%), Joint effusion (2%) <1% Angioedema, Arthritis, Herpetic eruptions, Thrombocytopenia, Peripheral edema, Vasovagal reaction, Hives, Gait disturbances

Mechanism of Action

Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour.

Note

RIBOLISIN 0.15% Eye Drops, Solution manufactured by Sooft Italia SBA. Its generic name is Sodium Hyaluronate. RIBOLISIN is availble in Saudi Arabia. Farmaco SA drug index information on RIBOLISIN Eye Drops, Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Sodium Hyaluronate :

Solution for Injection

ORTHOVISC ^{15 mg/ml}

3M HEALTH CARE LIMITED

Eye Drops

HYLO-COMOD ^0.1%

CADILA HEALTH CARE LIMITED

Solution for Injection

HYALGAN ^{10 mg/ml}

CADILA PHARMACEUTICALS LIMITED

Eye Drops

BIOSOFT ^0.2%

DENK PHARMA GmbH & Co. KG ,

Implant in Pre-filled Syringe

Z FILL CONTOUR ^{23 mg/ml}

DESBERGER LAB.