ROXIL Powder for Oral Suspension

Cefadroxil

50 mg/ml

ABBOTT FRANCE

Pack size	1 Bottle (100 ml)
Dispensing mode
Source
Agent
Retail Price	24.60 AED

Available as:

500 mg - Capsule, Hard

Indications

ROXIL Powder for Oral Suspension is used for: Pharyngitis, Susceptible infections, Sore throat, Tonsillitis, Urinary tract infection, Reproductive tract infection, Skin infections

Adult Dose

Oral Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections Adult: 1-2 g daily as a single or in 2 divided doses. Hepatic impairment: No dosage adjustment needed.

Child Dose

Oral Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections Child: >6 yr <40 kg: 30-50 mg/kg daily as a single or in 2 divided doses, up to 100 mg/kg daily.

Renal Dose

Renal impairment: CrCl (ml/min) 26-50 0.5-1 g bid. 11-25 0.5-1 g once daily. <10 0.5-1 g every 36 hr.

Administration

May be taken with or without food. May be taken w/ meals to reduce GI discomfort.

Contra Indications

Hypersensitivity to cephalosporins.

Precautions

Impaired renal function; pregnancy and lactation. Lactation: enters breast milk; use with caution

Pregnancy-Lactation

Pregnancy Category: B Lactation: enters breast milk; use with caution

Interactions

Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.

Adverse Effects

Side effects of Cefadroxil : 1-10% Diarrhea <1% Abdominal pain, Dyspepsia, Nausea, Vomiting, Rash, Urticaria, Pseudomembranous colitis, Stevens-Johnson syndrome, Anaphylaxis, Transaminases increased, Neutropenia Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Mechanism of Action

Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.

Note

ROXIL 50 mg/ml Powder for Oral Suspension manufactured by ABBOTT FRANCE. Its generic name is Cefadroxil. ROXIL is availble in Saudi Arabia. Farmaco SA drug index information on ROXIL Powder for Oral Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Cefadroxil :

Oral Suspension

MIDROXIL ^{100 mg/ml}

ALLERGAN PHARMACEUTICALS (IRELAND) LTD.

Capsule

MIDROXIL ^{500 mg}

ALLERGAN PHARMACEUTICALS (IRELAND) LTD.

Oral Suspension

MIDROXIL ^{50 mg/ml}

ALLERGAN PHARMACEUTICALS (IRELAND) LTD.

CEFADROX ^{100 mg/ml}

ACINO MEA FZ-LLC MIDDLE EAST AFRICA SCIENTFIC OFFICE