Sirolimus Oral Solution
Sirolimus
1 mg/ml
Novitium Pharma LLC
| Pack size | 1 Bottle (60 ml) |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 1020.95 AED |
Indications
Sirolimus Oral Solution is used for:
For the prophylaxis of organ rejection in patients receiving renal transplants.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Sirolimus :
Mechanism of Action
Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.
Note
Sirolimus 1 mg/ml Oral Solution manufactured by Novitium Pharma LLC. Its generic name is Sirolimus. Sirolimus is availble in Saudi Arabia.
Farmaco SA drug index information on Sirolimus Oral Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.