Fludarabine Phosphate Solution for Injection/Infusion
Fludarabine phosphate
25 mg/ml
LES LABORATORIES NEAPOLIS PHARMA
| Pack size | 1 Vial (2 ml) |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 161.05 AED |
Indications
Fludarabine Phosphate Solution for Injection/Infusion is used for:
For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Fludarabine phosphate :
Mechanism of Action
Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Note
Fludarabine Phosphate 25 mg/ml Solution for Injection/Infusion manufactured by LES LABORATORIES NEAPOLIS PHARMA. Its generic name is Fludarabine phosphate. Fludarabine Phosphate is availble in Saudi Arabia.
Farmaco SA drug index information on Fludarabine Phosphate Solution for Injection/Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.